{
  "analysisDate": "2026-09-15",
  "analysisType": "Retrospective descriptive evidence-coverage audit",
  "source": {
    "url": "https://www.genomics.senescence.info/drugs/dataset.zip",
    "retrieved": "2026-09-15",
    "sha256": "d12f59717de60a207748f53bdbcdb484ed07e30d8608eb8e4a101e2a08d7fa80",
    "bytes": 45365
  },
  "csvSha256": "7ed9771440fa4e1e30be0d3c8e92d919254b572ab40c81e2440ba78c885401d4",
  "planSha256": "b3a39b85880030a83ee6be8b5e35c799720c7920819e34afb27a40cb5d7b6286",
  "counts": {
    "rows": 3423,
    "compound_names": 1046,
    "species_labels_exact": 38,
    "species_labels_casefold": 35,
    "references": 664,
    "missing_reference_rows": 0,
    "compound_species_reference_units_exact": 1592,
    "compound_species_reference_units_casefold": 1592,
    "multiple_species_compounds_exact": 207,
    "multiple_species_compounds_casefold": 207,
    "mouse_rows": 373,
    "mouse_compounds": 134,
    "multiple_mouse_reference_compounds": 23,
    "male_and_female_mouse_compounds": 89,
    "multiple_mouse_reference_and_both_sexes_compounds": 20,
    "duplicate_full_rows": 7,
    "mouse_missing_start_age_rows": 2,
    "mouse_missing_duration_rows": 3,
    "missing_start_age_rows": 3051,
    "missing_duration_rows": 3053
  },
  "secondary": {
    "all_reference_medians_positive": 9,
    "at_least_one_reference_median_nonpositive": 14
  },
  "verification": {
    "method": "Independent SQL aggregation over the same imported raw columns",
    "checks": 20,
    "passed": true
  },
  "releaseNotes": {
    "label": "Build 5, 2024-11-29",
    "listedRows": 3406,
    "listedDrugs": 1045,
    "csvRows": 3423,
    "notesMatchCsv": false
  },
  "limitations": [
    "Longevity-positive literature selection; not all attempted treatments. No efficacy base rate can be estimated.",
    "Exact trimmed compound names, not chemical identities. Combinations and synonyms are not resolved.",
    "Species casefold sensitivity merges capitalization only, not taxonomy synonyms.",
    "Different PubMed identifiers do not establish independent labs, cohorts or successful replication.",
    "Rows sharing study controls are dependent. Unique compound-species-reference units are still not necessarily independent.",
    "Male and female coverage may come from different strains, ages, laboratories and conditions.",
    "Reference medians are descriptive mixtures; they do not pool causal effects, establish significance or translate to humans.",
    "This audit establishes data coverage, not a novel longevity intervention or a treatment recommendation."
  ],
  "attribution": "DrugAge, Human Ageing Genomic Resources; Barardo et al., Aging Cell 2017, doi:10.1111/acel.12585"
}